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Pragmatic trials are studies designed to provide information for the practice of clinical trials in real life. They are often focused on the practical aspects of the research design, like recruitment and consent, adherence, and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from various geographical areas. This kind of heterogeneity, which is essential for a pragmatic trial to be valid and lessen the chance of bias is also essential. However, too much heterogeneity can cause issues with the design of the trial.

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In addition to their mobile-friendly slot machines, Pragmatic Play also offers table games and live dealer casinos. Pragmatic Play is licensed by a variety of regulatory bodies such as Malta Gaming Authority and UK Gambling Commission. The games are protected by high-end encryption, and the company's security team is on hand to help players resolve any issues they might face.

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Pragmatic Play is renowned for its top-notch games, and also for providing an outstanding user experience. Its software is designed to work on mobile devices and supports different languages. It has earned itself the status of one of the leading gaming platforms in the casino industry despite its relatively young age. Wolves is one of the most recent releases which is a five-reel slot machine that has a high RTP and 무료 프라그마틱 impressive graphics. Other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to replicate real-life scenarios and gain the highest level of validity externally. They are usually commissioned by policy makers and practitioners to inform their decision making. They can be used to determine the cause-effect relationship of an intervention and its results. They should, however, not be used to replace explanation studies.

The pragmatism concept is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 made an distinction between explanation-based studies, which prove the validity of a physiological or clinical hypothesis, and pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the traits of a pragmatic study that includes recruitment, design, implementation of the intervention and its follow-up.

The number of pragmatic trials is growing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This is an indication that the health sciences community is becoming more sensitive to the issue of pragmatic thinking. It is important to remember, however, that the majority of these studies were conducted in primary care settings.